Usage of Oxaliplatin:
Oxaliplatin was developed as an advanced colorectal cancer treatment. The compound features a square planar platinum(II) center. In contrast to cisplatin and carboplatin, oxaliplatin features the bidentate ligand 1,2-diaminocyclohexane in place of the two monodentate ammine ligands. It also features a bidentate oxalate group.
The cytotoxicity of platinum compounds is thought to result from inhibition of DNA synthesis in cancer cells. In vivo studies showed that Oxaliplatin has anti-tumor activity against colon carcinoma through its (non-targeted) cytotoxic effects.
Oxaliplatin functions by forming both inter- and intra- strand cross links in DNA. Cross links in DNA prevent DNA replication and transcription, resulting in cell death. Oxaliplatin is typically administered with fluorouracil and leucovorin in a combination known as FOLFOX for the treatment of colorectal cancer.
Solubility:Oxaliplatin is soluble in water and is being subscribed to the patient in a liquid form.
At our Site:Ofichem produces Oxaliplatin solely as an active pharmaceutical ingredient on its own site in the Netherlands. In fact, it is produced in a dedicated workshop under EU-GMP conditions. You can check our documentation availability in the table on the right or you can visit our company productdatabase, from where you can download several documents.
Formula structure of Oxaliplatin: